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Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria
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SYSNO ASEP 0508598 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria Author(s) Ošťádal, Bohuslav (FGU-C) RID, ORCID
Drahota, Zdeněk (FGU-C) RID, ORCID
Houštěk, Josef (FGU-C) RID, ORCID
Milerová, Marie (FGU-C)
Ošťádalová, Ivana (FGU-C) RID
Hlaváčková, Markéta (FGU-C) RID, ORCID
Kolář, František (FGU-C) RID, ORCID, SAISource Title Canadian Journal of Physiology and Pharmacology. - : Canadian Science Publishing - ISSN 0008-4212
Roč. 97, č. 9 (2019), s. 808-814Number of pages 7 s. Language eng - English Country CA - Canada Keywords neonatal heart ; female heart ; ischemia-reperfusion injury ; cardiac ischemic tolerance ; mitochondrial permeability transition pore ; calcium-induced swelling Subject RIV ED - Physiology OECD category Physiology (including cytology) R&D Projects GA18-03461S GA ČR - Czech Science Foundation (CSF) GJ19-04790Y GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000483022200003 EID SCOPUS 85068336761 DOI 10.1139/cjpp-2019-0060 Annotation Age and sex play an essential role in the cardiac tolerance to ischemia-reperfusion injury: cardiac resistance significantly decreases during postnatal maturation and the female heart is more tolerant than the male myocardium. It is widely accepted that mitochondrial dysfunction, and particularly mitochondrial permeability transition pore (MPTP) opening, plays a major role in determining the extent of cardiac ischemia-reperfusion injury. We have observed that the MPTP sensitivity to the calcium load differs in mitochondria isolated from neonatal and adult myocardium, as well as from adult male and female hearts. Neonatal and female mitochondria are more resistant both in the extent and in the rate of mitochondrial swelling induced by high calcium concentration. Our data further suggest that age-and sex-dependent specificity of the MPTP is not the result of different amounts of ATP synthase and cyclophilin D: neonatal and adult hearts, similarly as the male and female hearts, contain comparable amounts of MPTP and its regulatory protein cyclophilin D. We can speculate that the lower sensitivity of MPTP to the calcium-induced swelling may be related to the higher ischemic tolerance of both neonatal and female myocardium. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2020 Electronic address https://www.nrcresearchpress.com/doi/10.1139/cjpp-2019-0060#.XljPJKhKiUk
Number of the records: 1