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Determination of Three Tumor Biomarkers (Homovanillic Acid, Vanillylmandelic Acid, and 5‐Hydroxyindole‐3‐Acetic Acid) Using Flow Injection Analysis with Amperometric Detection
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SYSNO ASEP 0498457 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Determination of Three Tumor Biomarkers (Homovanillic Acid, Vanillylmandelic Acid, and 5‐Hydroxyindole‐3‐Acetic Acid) Using Flow Injection Analysis with Amperometric Detection Author(s) Němečková-Makrlíková, Anna (UFCH-W)
Matysik, F.-M. (DE)
Navrátil, Tomáš (UFCH-W) RID, ORCID
Barek, J. (CZ)
Vyskočil, V. (CZ)Source Title Electroanalysis. - : Wiley - ISSN 1040-0397
Roč. 31, č. 2 (2019), s. 303-308Number of pages 6 s. Language eng - English Country DE - Germany Keywords screen-printed carbon electrodes ; flow injection analysis ; amerometric detection Subject RIV CG - Electrochemistry OECD category Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis) R&D Projects GA17-03868S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UFCH-W - RVO:61388955 UT WOS 000459630500018 EID SCOPUS 85055247557 DOI 10.1002/elan.201800540 Annotation Flow injection analysis with amperometric detection (FIA‐AD) at screen‐printed carbon electrodes (SPCEs) in optimum medium of Britton‐Robinson buffer (0.04 mol ⋅ L−1, pH 2.0) was used for the determination of three tumor biomarkers (homovanillic acid (HVA), vanillylmandelic acid (VMA), and 5‐hydroxyindole‐3‐acetic acid (5‐HIAA)). Dependences of the peak current on the concentration of biomarkers were linear in the whole tested concentration range from 0.05 to 100 μmol ⋅ L−1, with limits of detection (LODs) of 0.065 μmol ⋅ L−1 for HVA, 0.053 μmol ⋅ L−1 for VMA, and 0.033 μmol ⋅ L−1 for 5‐HIAA (calculated from peak heights), and 0.024 μmol ⋅ L−1 for HVA, 0.020 μmol ⋅ L−1 for VMA, and 0.012 μmol ⋅ L−1 for 5‐HIAA (calculated from peak areas), respectively.
Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2020 Electronic address http://hdl.handle.net/11104/0290822
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