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New Urea Derivatives Are Effective Anti-senescence Compounds Acting Most Likely via a Cytokinin-Independent Mechanism
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SYSNO ASEP 0494180 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title New Urea Derivatives Are Effective Anti-senescence Compounds Acting Most Likely via a Cytokinin-Independent Mechanism Author(s) Nisler, Jaroslav (UEB-Q) RID, ORCID
Zatloukal, M. (CZ)
Sobotka, Roman (MBU-M) RID, ORCID
Pilný, Jan (MBU-M) ORCID
Zdvihalová, Barbora (MBU-M)
Novák, Ondřej (UEB-Q) RID, ORCID, SAI
Strnad, Miroslav (UEB-Q) RID, ORCID
Spíchal, L. (CZ)Number of authors 8 Article number 1225 Source Title Frontiers in Plant Science. - : Frontiers Research Foundation - ISSN 1664-462X
Roč. 9, SEP 11 (2018)Number of pages 17 s. Language eng - English Country CH - Switzerland Keywords induced leaf senescence ; wheat triticum-aestivum ; arabidopsis-thaliana ; abscisic-acid ; gene-expression ; abiotic stress ; salt stress ; chlorophyll degradation ; cucumber cotyledons ; biological-activity ; ases ; cytokinin ; photosystem II ; senescence ; stress ; thidiazuron ; wheat Subject RIV EE - Microbiology, Virology OECD category Plant sciences, botany R&D Projects LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LO1416 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2015055 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEB-Q - RVO:61389030 ; MBU-M - RVO:61388971 UT WOS 000444240700001 DOI 10.3389/fpls.2018.01225 Annotation Stress-induced senescence is a global agro-economic problem. Cytokinins are considered to be key plant anti-senescence hormones, but despite this practical function their use in agriculture is limited because cytokinins also inhibit root growth and development. We explored new cytokinin analogs by synthesizing a series of 1,2,3-thiadiazol-5-yl urea derivatives. The most potent compound, 1-(2-methoxy-ethyl)-3-1,2,3-thiadiazol-5-yl urea (ASES Anti-Senescence Substance), strongly inhibited dark-induced senescence in leaves of wheat (Triticum aestivum L.) and Arabidopsis thaliana. The inhibitory effect of ASES on wheat leaf senescence was, to the best of our knowledge, the strongest of any known natural or synthetic compound. In vivo, ASES also improved the salt tolerance of young wheat plants. Interestingly, ASES did not affect root development of wheat and Arabidopsis, and molecular and classical cytokinin bioassays demonstrated that ASES exhibits very low cytokinin activity. A proteomic analysis of the ASES-treated leaves further revealed that the senescence-induced degradation of photosystem II had been very effectively blocked. Taken together, our results including data from cytokinin content analysis demonstrate that ASES delays leaf senescence by mechanism(s) different from those of cytokinins and, more effectively. No such substance has yet been described in the literature, which makes ASES an interesting tool for research of photosynthesis regulation. Its simple synthesis and high efficiency predetermine ASES to become also a potent plant stress protectant in biotechnology and agricultural industries. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2019
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