Semi-parametric arterial input functions for quantitative dynamic contrast enhanced magnetic resonance imaging in mice

0489561 - ÚPT 2019 RIV US eng J - Journal Article
Taxt, T. - Reed, R. K. - Pavlin, T. - Rygh, C. B. - Andersen, E. - Jiřík, Radovan
Semi-parametric arterial input functions for quantitative dynamic contrast enhanced magnetic resonance imaging in mice.
Magnetic Resonance Imaging. Roč. 46, FEB (2018), s. 10-20. ISSN 0730-725X. E-ISSN 1873-5894
R&D Projects: GA MŠMT(CZ) LO1212; GA ČR(CZ) GA16-13830S
Institutional support: RVO:68081731
Keywords : DCE-MRI * blind deconvolution * arterial input function
OECD category: Medical laboratory technology (including laboratory samples analysis
Impact factor: 2.112, year: 2018

Objective: An extension of single- and multi channel blind deconvolution is presented to improve the estimation of the arterial input function (AIF) in quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI).
Methods: The Lucy-Richardson expectation-maximization algorithm is used to obtain estimates of the AIF and the tissue residue function (TRF). In the first part of the algorithm, nonparametric estimates of the AIF and TRF are obtained. In the second part, the decaying part of the AIF is approximated by three decaying exponential
functions with the same delay, giving an almost noise free semi-parametric AIF. Simultaneously, the TRF is approximated using the adiabatic approximation of the Johnson-Wilson (aaJW) pharmacokinetic model.
Results: In simulations and tests on real data, use of this AIF gave perfusion values close to those obtained with the corresponding previously published nonparametric AIF, and are more noise robust.
Conclusion: When used subsequently in voxelwise perfusion analysis, these semi-parametric AIFs should give more correct perfusion analysis maps less affected by recording noise than the corresponding nonparametric AIFs, and AIFs obtained from arteries.
Significance: This paper presents a method to increase the noise robustness in the estimation of the perfusion parameter values in DCE-MRI.
Permanent Link: http://hdl.handle.net/11104/0283959