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Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans
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SYSNO ASEP 0484026 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans Author(s) Stejskalová, K. (CZ)
Bayerova, Z. (CZ)
Futas, J. (CZ)
Hrazdilová, K. (CZ)
Klumplerova, M. (CZ)
Oppelt, J. (CZ)
Šplíchalová, P. (CZ)
Di Guardo, G. (IT)
Mazzariol, S. (IT)
Di Francesco, C. E. (IT)
Di Francesco, G. (IT)
Terracciano, G. (IT)
Paiu, R.M. (RO)
Ursache, T. D. (RO)
Modrý, David (BC-A) RID, ORCID
Horin, P. (CZ)Number of authors 16 Source Title HLA - ISSN 2059-2302
Roč. 90, č. 6 (2017), s. 343-353Number of pages 11 s. Publication form Print - P Language eng - English Country US - United States Keywords Cetacea ; haplotype ; immunity ; innate ; mhc-dqb ; Phocoena phocoena ; polymorphism ; single nucleotide ; Stenella coeruleoalba Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology Institutional support BC-A - RVO:60077344 UT WOS 000415933600003 EID SCOPUS 85034423447 DOI 10.1111/tan.13146 Annotation Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity-related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced 11 candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena. Suitable single nucleotide polymorphism markers of potential functional importance, located in genes coding for basigin (BSG, CD147), the signaling lymphocyte activating molecule (SLAMF1), the poliovirus-related receptor-4 (NECTIN4, PVRL4), toll-like receptors 3, 7, 8 (TLR3, TLR7, TLR8), natural resistance-associated macrophage protein (SLC11A1) and natural cytotoxicity triggering receptor 1 (NCR1), were identified in each model species, along with MHC-DQB haplotypes unique for each species. This set of molecular markers represents a potentially useful tool for studying host genetic variation and susceptibility to morbillivirus infection in Cetaceans as well as for studying functionally important genetic diversity of selected Cetacean populations. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2018
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