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Oocytes
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SYSNO ASEP 0483024 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Translational regulation in the mammalian oocyte Author(s) Šušor, Andrej (UZFG-Y) RID, ORCID
Kubelka, Michal (UZFG-Y) RID, ORCIDSource Title Oocytes. - Wien : Springer International Publishing, 2017 - ISBN 978-3-319-60855-6 Pages s. 257-295 Number of pages 39 s. Number of copy 500 Number of pages 260 Publication form Print - P Language eng - English Country AT - Austria Keywords mammalian oocyte Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology R&D Projects GA13-12291S GA ČR - Czech Science Foundation (CSF) GA15-22765S GA ČR - Czech Science Foundation (CSF) EF15_003/0000460 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UZFG-Y - RVO:67985904 UT WOS 000440267800013 EID SCOPUS 85027255073 DOI 10.1007/978-3-319-60855-6_12 Annotation Fully grown oocytes arrest meiosis at prophase I and deposit maternal RNAs. A subset of maternal transcripts is stored in a dormant state in the oocyte, and the timely driven translation of specific mRNAs guides meiotic progression, the oocyte-embryo transition, and early embryo development. In the absence of transcription, the regulation of gene expression in oocytes is controlled almost exclusively at the level of transcriptome and proteome stabilization and at the level of protein synthesis. This chapter focuses on the recent findings on RNA distribution related to the temporal and spatial translational control of the meiotic cycle progression in mammalian oocytes. We discuss the most relevant mechanisms involved in the organization of the oocyte’s maternal transcriptome storage and localization, and the regulation of translation, in correlation with the regulation of oocyte meiotic progression. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2018
Number of the records: 1