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MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis
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SYSNO ASEP 0480904 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis Author(s) Schneiderová, B. (CZ)
Naccarati, Alessio (UEM-P)
Pardini, Barbara (UEM-P)
Rosa, F. (IT)
Di Gaetano, C. (IT)
Jirásková, Kateřina (UEM-P)
Opattová, Alena (UEM-P)
Levý, M. (CZ)
Veskrna, K. (CZ)
Veškrnová, V. (CZ)
Buchler, T. (CZ)
Landi, S. (IT)
Vodička, Pavel (UEM-P) RID
Vymetálková, Veronika (UEM-P) RIDSource Title Mutagenesis. - : Oxford University Press - ISSN 0267-8357
Roč. 32, č. 5 (2017), s. 533-542Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords excision-repair genes ; bladder-cancer ; tumor-growth Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology R&D Projects NV15-26535A GA MZd - Ministry of Health (MZ) LD14050 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) NV15-27580A GA MZd - Ministry of Health (MZ) GA17-16857S GA ČR - Czech Science Foundation (CSF) Institutional support UEM-P - RVO:68378041 UT WOS 000413218700007 EID SCOPUS 85032489277 DOI 10.1093/mutage/gex026 Annotation Here we provide the first evidence that variations in potential miRNA target binding sites in the 3UTR of PARP1 gene may modulate CRC risk and prognosis after therapy. We investigated eight miRSNPs (rs1804191, rs397768, rs41116 in APC, rs1137918, s227091, rs4585 in ATM, rs712, rs1137282, rs61764370 in KRAS, rs8674 in PARP1 and rs16950113 in SMAD7) for their association with CRC risk in a case–control study (1111 cases and 1469 healthy controls). The role of these miRSNPs was also investigated in relation to clinical outcome on a subset of patients with complete follow-up. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2018
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