Reconstitution of cytomegalovirus-specific T-cell response in allogeneic hematopoietic stem cell recipients: the contribution of six frequently recognized, virus-encoded ORFs

0478042 - ÚI 2018 US eng J - Journal Article
Němečková, Š. - Kryštofová, J. - Babiarová, K. - Hainz, P. - Musil, J. - Šroller, J. - Malý, Marek - Šťastná-Marková, M.
Reconstitution of cytomegalovirus-specific T-cell response in allogeneic hematopoietic stem cell recipients: the contribution of six frequently recognized, virus-encoded ORFs.
Transplant Infectious Disease. Roč. 18, č. 3 (2016), s. 381-389. ISSN 1398-2273. E-ISSN 1399-3062
Keywords : identify patients * flow-cytometry * host-disease * ctl epitopes * transplantation * infection * cmv * cd4(+) * identification * replication * human cytomegalovirus * T cell * allogeneic stem cell transplantation * elispot * interferon-gamma
Impact factor: 1.719, year: 2016

BackgroundThe reactivation of human cytomegalovirus (HCMV) in immunosuppressed patients is associated with significant morbidity. Testing HCMV-specific T-cell responses can help determine which patients are at high risk of HCMV disease. We optimized selection of HCMV antigens for detection of T-cell response of patients after allogeneic hematopoietic stem cell transplantation (HSCT) with the aim of identifying patients with insufficient control of HCMV reactivation.
Permanent Link: http://hdl.handle.net/11104/0274306