Synthesis, characterization and in vitro biological activities of new water-soluble copper(II), zinc(II), and nickel(II) complexes with sulfonato-substituted Schiff base ligand

0473837 - FZÚ 2018 RIV NL eng J - Journal Article
Hosseini-Yazdi, S.A. - Mirzaahmadi, A. - Khandar, A.A. - Eigner, Václav - Dušek, Michal - Lotfipour, F. - Mahdavi, M. - Soltani, S. - Dehghan, G.
Synthesis, characterization and in vitro biological activities of new water-soluble copper(II), zinc(II), and nickel(II) complexes with sulfonato-substituted Schiff base ligand.
Inorganica chimica acta. Roč. 458, Mar (2017), s. 171-180. ISSN 0020-1693. E-ISSN 1873-3255
R&D Projects: GA ČR(CZ) GA15-12653S; GA MŠMT(CZ) LO1603
EU Projects: European Commission(XE) CZ.2.16/3.1.00/24510
Institutional support: RVO:68378271
Keywords : water-soluble Schiff base * thiosemicarbazone * antimicrobial * antioxidant * cytotoxicity * crystal structure
OECD category: Inorganic and nuclear chemistry
Impact factor: 2.264, year: 2017

A water-soluble thiosemicarbazone Schiff base ligand, namely sodium 3-{[(aminocarbonothioyl)hydrazono]methyl}-4-hydroxybenzenesulfonate (NaH2L) was prepared by 1:1 condensation of sodium salicylaldehyde-5-sulfonate and thiosemicarbazide. The X-ray structure analysis of NaH2L shows that the organic fragments of the ligand are bridged by two different types of seven-coordinated sodium cations. The ligand was used in the synthesis of the following CuII, NiII, and ZnII complexes: [Cu2(HL)2(H2O)3] (1), Ni(HL)(H2O)1.5 (2), and Zn(HL)(H2O)2 (3). The metal complexes were characterized by physico-chemical and spectroscopic methods. The X-ray structure analysis of the dinuclear copper complex (1) shows that two metal centers are five coordinated having distorted square pyramidal geometries.
Permanent Link: http://hdl.handle.net/11104/0270964