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Nitro-Oleic Acid Prevents Hypoxia- and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction
- 1.0471939 - BFÚ 2017 RIV NL eng J - Journal Article
Koudelka, Adolf - Ambrožová, Gabriela - Klinke, A. - Fidlerová, Táňa - Martíšková, Hana - Kuchta, R. - Rudolph, T.K. - Kadlec, J. - Kuchtová, Z. - Woodcock, S.R. - Freeman, B.A. - Kubala, Lukáš - Pekarová, Michaela
Nitro-Oleic Acid Prevents Hypoxia- and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction.
Cardiovascular Drugs and Therapy. Roč. 30, č. 6 (2016), s. 579-586. ISSN 0920-3206. E-ISSN 1573-7241
R&D Projects: GA ČR GP13-40824P; GA MŠMT(CZ) LD15069
Institutional support: RVO:68081707
Keywords : fatty acids * arterial-hypertension * oxide synthase * murine model
Subject RIV: BO - Biophysics
Impact factor: 2.820, year: 2016
Pulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aimed to explore the effect of nitro-oleic acid (OA-NO2), an exemplary nitro-fatty acid (NO2-FA), in human pulmonary artery endothelial cells (HPAEC) under the influence of hypoxia or ADMA.
Permanent Link: http://hdl.handle.net/11104/0269301
Number of the records: 1