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Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer
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SYSNO ASEP 0469362 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer Author(s) Vodička, Pavel (UEM-P) RID
Pardini, Barbara (UEM-P)
Vymetálková, Veronika (UEM-P) RID
Naccarati, Alessio (UEM-P)Source Title Advances in Experimental Medicine and Biology - ISSN 0065-2598
Roč. 937, č. 2016 (2016), s. 123-149Number of pages 29 s. Language eng - English Country US - United States Keywords colorectal cancer ; polymorphism ; risk factors Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology R&D Projects NV15-26535A GA MZd - Ministry of Health (MZ) GA15-08239S GA ČR - Czech Science Foundation (CSF) Institutional support UEM-P - RVO:68378041 UT WOS 000399043400008 EID SCOPUS 84984998999 DOI 10.1007/978-3-319-42059-2_7 Annotation Colorectal cancer (CRC) is a complex disease that develops as a consequence of both genetic and environmental risk factors in interplay with epigenetic mechanisms, such as microRNAs (miRNAs). CRC cases are predominantly sporadic in which the disease develops with no apparent hereditary syndrome. The last decade has seen the progress of genome-wide association studies (GWAS) that allowed the discovery of several genetic regions and variants associated with weak effects on sporadic CRC. Collectively these variants may enable a more accurate prediction of an individual's risk to the disease and its prognosis. However, the number of variants contributing to CRC is still not fully explored.SNPs in genes encoding the miRNA sequence or in 3'UTR regions of the corresponding binding sites may affect miRNA transcription, miRNA processing, and/or the fidelity of the miRNA-mRNA interaction. These variants could plausibly impact miRNA expression and target mRNA translation into proteins critical for cellular integrity, differentiation, and proliferation.In the present chapter, we describe the different aspects of variations related to miRNAs and other non-coding RNAs (ncRNAs) and evidence from studies investigating these candidate genetic alterations in support to their role in CRC development and progression. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2017
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