Number of the records: 1
Regioselective Palmitoylation of 9-(2,3-Dihydroxy-propyl)adenine Catalyzed by a Glycopolymer-enzyme Conjugate
- 1.0463426 - ÚOCHB 2017 RIV CH eng J - Journal Article
Brabcová, Jana - Blažek, Jiří - Krečmerová, Marcela - Vondrášek, Jiří - Palomo, J. M. - Zarevúcka, Marie
Regioselective Palmitoylation of 9-(2,3-Dihydroxy-propyl)adenine Catalyzed by a Glycopolymer-enzyme Conjugate.
Molecules. Roč. 21, č. 5 (2016), č. článku 648. E-ISSN 1420-3049
Grant - others:AV ČR(CZ) M200551203
Institutional support: RVO:61388963
Keywords : regioselectivity * palmitoylation * glycosylation * chemical modification
Subject RIV: CE - Biochemistry
Impact factor: 2.861, year: 2016
http://www.mdpi.com/1420-3049/21/5/648/htm
The enzymatic regioselective monopalmitoylation of racemic 9-(2,3-dihydroxypropyl)adenine (DHPA), an approved antiviral agent, has been performed by an immobilized form of Candida antarctica B lipase (CAL-B) using a 4: 1 DMF/hexane mixture as the reaction medium. To improve the chemical yield of the desired monopalmitoylation reaction, solid-phase chemical modifications of the lipase were evaluated. The reaction yield was successfully increased obtaining 100% product after a second treatment of the product solution with fresh immobilised chemically glycosylated-CAL-B.
Permanent Link: http://hdl.handle.net/11104/0262627
Number of the records: 1