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Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications
- 1.0458295 - ÚMCH 2017 RIV GB eng J - Journal Article
Jäger, Eliezer - Höcherl, Anita - Janoušková, Olga - Jäger, Alessandro - Hrubý, Martin - Konefal, Rafal - Netopilík, Miloš - Pánek, Jiří - Šlouf, Miroslav - Ulbrich, Karel - Štěpánek, Petr
Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications.
Nanoscale. Roč. 8, č. 13 (2016), s. 6958-6963. ISSN 2040-3364. E-ISSN 2040-3372
R&D Projects: GA MŠMT(CZ) 7F14009; GA MPO(CZ) FR-TI4/625; GA MŠMT(CZ) LH14292; GA MŠMT(CZ) LO1507; GA TA ČR(CZ) TE01020118
Institutional support: RVO:61389013
Keywords : reactive oxygen species (ROS) * responsive nanoparticles * fluorescence life-time imaging (FLIM)
Subject RIV: CC - Organic Chemistry
Impact factor: 7.367, year: 2016
A new drug-delivery system of polymer nanoparticles (NPs) bearing pinacol-type boronic ester and alkyne moieties displaying triggered self-immolative polymer degradation in the presence of reactive oxygen species (ROS) with the capability of cellular imaging is presented. The NPs specifically release their drug cargo under concentrations of ROS that are commonly found in the intracellular environment of certain tumors and of inflamed tissues and exhibit significant cytotoxicity to cancer cells compared to their non-ROS-responsive counterparts.
Permanent Link: http://hdl.handle.net/11104/0258578
Number of the records: 1