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Pharmacological caspase inhibitors: Research towards therapeutic perspectives
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SYSNO ASEP 0457852 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Pharmacological caspase inhibitors: Research towards therapeutic perspectives Author(s) Kudělová, J. (CZ)
Fleischmannová, Jana (UZFG-Y)
Adamová, Eva (UZFG-Y)
Matalová, Eva (UZFG-Y) RIDSource Title Journal of Physiology and Pharmacology. - : Polskie Towarzystwo Fizjologiczne - ISSN 0867-5910
Roč. 66, č. 4 (2015), s. 473-482Number of pages 10 s. Publication form Print - P Language eng - English Country PL - Poland Keywords caspase ; caspase inhibitor ; apoptosis Subject RIV EB - Genetics ; Molecular Biology R&D Projects GB14-37368G GA ČR - Czech Science Foundation (CSF) Institutional support UZFG-Y - RVO:67985904 UT WOS 000361499800001 EID SCOPUS 84940744287 Annotation Caspases are key molecules of apoptosis and the inflammatory response. Up-regulation of the caspase cascade contributes to human pathologies such as neurodegenerative and immune disorders. Thus, blocking the excessive apoptosis by pharmacological inhibitors seems promising for therapeutic interventions in such diseases. Caspase inhibitors, both natural and artificial, have been used as research tools and have helped to define the role of the individual caspases in apoptosis and in non-apoptotic processes. Moreover, some caspase inhibitors have demonstrated their therapeutic efficiency in the reduction of cell death and inflammation in animal models of human diseases. However, no drug based on caspase inhibition has been approved on the market until now. Thus, the development of therapeutic approaches that specifically target caspases remains a great challenge and is now the focus of intense biological and clinical interest. Here, we provide a brief review of recent knowledge about pharmacological caspase inhibitors with special focus on their proposed clinical applications. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2016
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