Number of the records: 1  

Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol

  1. 1.
    SYSNO ASEP0451351
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleDay-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol
    Author(s) Topinka, Jan (UEM-P) RID, ORCID
    Rössner ml., Pavel (UEM-P) RID, ORCID
    Milcová, Alena (UEM-P)
    Schmuczerová, Jana (UEM-P) RID
    Pěnčíková, K. (CZ)
    Rössnerová, Andrea (UEM-P) RID
    Ambrož, Antonín (UEM-P)
    Štolcpartová, Jitka (UEM-P)
    Bendl, J. (CZ)
    Hovorka, J. (CZ)
    Machala, M. (CZ)
    Number of authors11
    Source TitleEnvironmental Pollution. - : Elsevier - ISSN 0269-7491
    Roč. 202, jul (2015), s. 135-145
    Number of pages11 s.
    Languageeng - English
    CountryGB - United Kingdom
    Keywordsair pollution ; carcinogenic PAH ; dioxin-like activity ; DNA adducts ; oxidative damage ; particulate matter
    Subject RIVDN - Health Impact of the Environment Quality
    R&D ProjectsGBP503/12/G147 GA ČR - Czech Science Foundation (CSF)
    Institutional supportUEM-P - RVO:68378041
    UT WOS000354581900017
    EID SCOPUS84925844096
    DOI10.1016/j.envpol.2015.03.024
    AnnotationThis study quantified the temporal variability of concentration of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs), genotoxicity, oxidative DNA damage and dioxin-like activity of the extractable organic matter (EOM) of atmospheric aerosol particles of aerodynamic diameter (d(ae), mu m) coarse (1 < d(ae) < 10), upper- (0.5 < d(ae) < 1) and lower-accumulation (0.17 < d(ae) < 0.5) and ultrafine (<0.17) fractions. The upper accumulation fraction formed most of the aerosol mass for 22 of the 26 study days and contained 44% of total c-PAHs, while the ultrafine fraction contained only 11%. DNA adduct levels suggested a crucial contribution of c-PAHs bound to the upper accumulation fraction. The dioxin-like activity was also driven primarily by c-PAH concentrations. In contrast, oxidative DNA damage was not related to c-PAHs, as a negative correlation with c-PAHs was observed. These results suggest that genotoxicity and dioxin-like activity are the major toxic effects of organic compounds bound to size segregated aerosol, while oxidative DNA damage is not induced by EOM. (C) 2015 Elsevier Ltd. All rights reserved.
    WorkplaceInstitute of Experimental Medicine
    ContactLenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
    Year of Publishing2016
Number of the records: 1  

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