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Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol
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SYSNO ASEP 0451351 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol Author(s) Topinka, Jan (UEM-P) RID, ORCID
Rössner ml., Pavel (UEM-P) RID, ORCID
Milcová, Alena (UEM-P)
Schmuczerová, Jana (UEM-P) RID
Pěnčíková, K. (CZ)
Rössnerová, Andrea (UEM-P) RID
Ambrož, Antonín (UEM-P)
Štolcpartová, Jitka (UEM-P)
Bendl, J. (CZ)
Hovorka, J. (CZ)
Machala, M. (CZ)Number of authors 11 Source Title Environmental Pollution. - : Elsevier - ISSN 0269-7491
Roč. 202, jul (2015), s. 135-145Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords air pollution ; carcinogenic PAH ; dioxin-like activity ; DNA adducts ; oxidative damage ; particulate matter Subject RIV DN - Health Impact of the Environment Quality R&D Projects GBP503/12/G147 GA ČR - Czech Science Foundation (CSF) Institutional support UEM-P - RVO:68378041 UT WOS 000354581900017 EID SCOPUS 84925844096 DOI 10.1016/j.envpol.2015.03.024 Annotation This study quantified the temporal variability of concentration of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs), genotoxicity, oxidative DNA damage and dioxin-like activity of the extractable organic matter (EOM) of atmospheric aerosol particles of aerodynamic diameter (d(ae), mu m) coarse (1 < d(ae) < 10), upper- (0.5 < d(ae) < 1) and lower-accumulation (0.17 < d(ae) < 0.5) and ultrafine (<0.17) fractions. The upper accumulation fraction formed most of the aerosol mass for 22 of the 26 study days and contained 44% of total c-PAHs, while the ultrafine fraction contained only 11%. DNA adduct levels suggested a crucial contribution of c-PAHs bound to the upper accumulation fraction. The dioxin-like activity was also driven primarily by c-PAH concentrations. In contrast, oxidative DNA damage was not related to c-PAHs, as a negative correlation with c-PAHs was observed. These results suggest that genotoxicity and dioxin-like activity are the major toxic effects of organic compounds bound to size segregated aerosol, while oxidative DNA damage is not induced by EOM. (C) 2015 Elsevier Ltd. All rights reserved. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2016
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