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Powerhouse down: Complex II dissociation in the respiratory chain
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SYSNO ASEP 0441825 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Powerhouse down: Complex II dissociation in the respiratory chain Author(s) Hwang, M.-S. (GB)
Rohlena, Jakub (BTO-N) RID, ORCID
Dong, L.-F. (AU)
Neužil, Jiří (BTO-N) RID
Grimm, S. (GB)Source Title Mitochondrion. - : Elsevier - ISSN 1567-7249
Roč. 19, Part A SI (2014), 20-28Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords Mitochondria ; Apoptosis ; Complex II Subject RIV EB - Genetics ; Molecular Biology R&D Projects ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GAP301/12/1851 GA ČR - Czech Science Foundation (CSF) Institutional support BTO-N - RVO:86652036 UT WOS 000346624700004 DOI 10.1016/j.mito.2014.06.001 Annotation Complex II of the respiratory chain (RC) recently emerged as a prominent regulator of cell death. In both cancer cells as well as neurodegenerative diseases, mutations in subunits have been found along with other genetic alterations indirectly affecting this complex. Anticancer compounds were developed that target complex II and cause cell death in a tumor-specific way. Our mechanistic understanding of how complex Ills activated for cell death induction has recently been made clearer in recent studies, the results of which are covered in this review. This protein assembly is specifically activated for cell death via the dissociation of its SDHA and SDHB subunits from the membrane-anchoring proteins through pH change or mitochondrial Ca2+ influx. The SDH activity contained in the SDHA/SDHB subcomplex remains intact and then generates, in an uncontrolled fashion, excessive amounts of reactive oxygen species (ROS) for cell death. Future studies on this mitochondrial complex will further elucidate it as a target for cancer treatments and reveal its role as a nexus for many diverse stimuli in cell death signaling. (C) 2014 Elsevier B.V. and Mitochondria Research Society. All rights reserved. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2015
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