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Natural variation of histone modification and its impact on gene expression in the rat genome
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SYSNO ASEP 0429012 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Natural variation of histone modification and its impact on gene expression in the rat genome Author(s) Rintisch, C. (DE)
Heinig, M. (DE)
Bauerfeind, A. (DE)
Schafer, S. (DE)
Mieth, Ch. (DE)
Patone, G. (DE)
Hummel, O. (DE)
Chen, W. (DE)
Cook, S. (GB)
Cuppen, E. (NL)
Colomé-Tatché, M. (NL)
Johannes, F. (NL)
Jansen, R. C. (NL)
Neil, H. (FR)
Werner, M. (FR)
Pravenec, Michal (FGU-C) RID, ORCID
Vingron, M. (DE)
Hubner, N. (DE)Source Title Genome Research. - : Cold Spring Harbor Laboratory Press - ISSN 1088-9051
Roč. 24, JUN (2014), s. 942-953Number of pages 12 s. Language eng - English Country US - United States Keywords ChIP-seq ; histone modification ; gene expression ; genetic linkage analysis Subject RIV EB - Genetics ; Molecular Biology R&D Projects 7E10067 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GAP301/10/0290 GA ČR - Czech Science Foundation (CSF) LL1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000336662200006 EID SCOPUS 84901847787 DOI 10.1101/gr.169029.113 Annotation Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. The integrated analysis of DNA variation together with histone methylation and gene expression levels showed that histone QTLs are an important predictor of gene expression and that a joint analysis significantly enhanced the prediction of gene expression traits (eQTLs). Our data suggest that genetic variation has widespread impact on histone trimethylation marks that may help to uncover novel genotype-phenotype relationships Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2015
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