Number of the records: 1
Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice
- 1.
SYSNO ASEP 0427968 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice Author(s) Hofer, Michal (BFU-R) RID, ORCID
Pospíšil, Milan (BFU-R)
Dušek, L. (CZ)
Hoferová, Zuzana (BFU-R) RID
Komůrková, Denisa (BFU-R) RID, ORCIDNumber of authors 5 Source Title Radiation and Environmental Biophysics - ISSN 0301-634X
Roč. 53, č. 1 (2014), s. 211-215Number of pages 5 s. Publication form Print - P Language eng - English Country DE - Germany Keywords Ionizing radiation ; Acute radiation disease ; Survival Subject RIV BO - Biophysics R&D Projects GA305/08/0158 GA ČR - Czech Science Foundation (CSF) GAP303/11/0128 GA ČR - Czech Science Foundation (CSF) Institutional support BFU-R - RVO:68081707 UT WOS 000331977300018 DOI 10.1007/s00411-013-0500-y Annotation here exists a requirement for drugs which would be useful in therapy of an acute radiation damage of a mammalian organism. The aim of the study was to evaluate survival parameters in mice exposed to a lethal gamma-ray dose of 8.5 Gy and treated with single doses of an adenosine A(3) receptor agonist, IB-MECA, or a cyclooxygenase-2 (COX-2) inhibitor, meloxicam, administered alone or in a combination early after irradiation, i.e., 0.5 and 1 h post-irradiation, respectively. The assessed parameters were the mean survival time (MST) and the cumulative percentage 30-day survival (CPS). Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation or meloxicam 1 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice. Combined administration of IB-MECA and meloxicam was found to be the only treatment statistically enhancing the parameter of CPS and to lead to the most expressive increase in MST of the experimental mice. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2015
Number of the records: 1