Mechanisms of the 14-3-3 protein function: regulation of protein function through conformational modulation

0427835 - FGÚ 2015 RIV CZ eng J - Journal Article
Obšilová, Veronika - Kopecká, Miroslava - Košek, Dalibor - Kacířová, M. - Kylarová, Salome - Řežábková, L. - Obšil, T.
Mechanisms of the 14-3-3 protein function: regulation of protein function through conformational modulation.
Physiological Research. Roč. 63, Suppl.1 (2014), S155-S164. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GAP207/11/0455
Grant - others:GA ČR(CZ) GAP305/11/0708
Institutional support: RVO:67985823
Keywords : 14-3-3 protein * regulator of G-protein signalling (RGS3), * phosducin * neutral trehalase * Bmh1 * conformation * signaling
Subject RIV: BO - Biophysics
Impact factor: 1.293, year: 2014

The 14-3-3 protein binding can affect the function of the target protein in many ways including the modulation of its enzyme activity, its subcellular localization, its structure and stability, or its molecular interactions. In this minireview, we focus on mechanisms of the 14-3-3 protein-dependent regulation of three important 14-3-3 binding partners: yeast neutral trehalase Nth1, regulator of G-protein signaling 3 (RGS3), and phosducin
Permanent Link: http://hdl.handle.net/11104/0233287