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A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs
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SYSNO ASEP 0424945 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs Author(s) Filová, E. (CZ)
Rampichová, M. (CZ)
Litvinec, Andrej (FGU-C)
Držík, M. (SK)
Míčková, A. (CZ)
Buzgo, M. (CZ)
Košťáková, E. (CZ)
Martinová, L. (CZ)
Usvald, D. (CZ)
Prosecká, E. (CZ)
Uhlík, J. (CZ)
Motlík, J. (CZ)
Vajner, L. (CZ)
Amler, E. (CZ)Source Title International Journal of Pharmaceutics. - : Elsevier - ISSN 0378-5173
Roč. 447, 1-2 (2013), s. 139-149Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords cartilage ; fibrin ; nanofibers Subject RIV FP - Other Medical Disciplines Institutional support FGU-C - RVO:67985823 UT WOS 000317310500017 EID SCOPUS 84875083803 DOI 10.1016/j.ijpharm.2013.02.056 Annotation A novel drug delivery system was developed on the basis of the intake effect of liposomes encapsulated in PVA nanofibers. Time-controlled release of insulin and bFGF improved MSC viability in vitro. In addition, cell-free composite scaffolds containing PVA nanofibers enriched with liposomes, bFGF, and insulin were implanted into seven osteochondral defects of miniature pigs; control defects were left untreated. The cell-free composite scaffold enhanced migration of the cells into the defect, and their differentiation into chondrocytes; the scaffold was able to enhance the regeneration of osteochondral defects in minipigs Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2014
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