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Upregulation of genes involved in cardiac metabolism enhances myocardial resistance to ischemia/reperfusion in the rat heart
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SYSNO ASEP 0422631 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Upregulation of genes involved in cardiac metabolism enhances myocardial resistance to ischemia/reperfusion in the rat heart Author(s) Ravingerová, T. (SK)
Čarnická, S. (SK)
Ledvényiová, V. (SK)
Barlaka, E. (GR)
Galatou, E. (GR)
Chytilová, Anna (FGU-C)
Mandíková, Petra (FGU-C)
Nemčeková, M. (SK)
Adameová, A. (SK)
Kolář, František (FGU-C) RID, ORCID, SAI
Lazou, A. (GR)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 62, Suppl.1 (2013), S151-S163Number of pages 13 s. Language eng - English Country CZ - Czech Republic Keywords myocardial ischemia ; PPAR activation ; metabolic genes ; delayed preconditioning ; WY-14643 Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects 7AMB12SK164 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000328901900017 EID SCOPUS 84891639182 Annotation The results indicate that cardioprotection was associated with remarkably increased expression of PPAR-alpha target genes promoting FA utilization and reduced expression of glucose transporter GLUT-4. Potential non-genomic effects of PPAR-alpha-mediated cardioprotection may involve activation of prosurvival PI3K/Akt pathway and its downstream targets such as eNOS and subsequently reduced apoptosis Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2014
Number of the records: 1