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Improved prediction of therapeutic absorbed doses of radioiodine in the treatment of thyroid carcinoma
- 1.0410625 - UTIA-B 20010094 RIV US eng J - Journal Article
Heřmanská, J. - Kárný, Miroslav - Zimák, J. - Jirsa, Ladislav - Šámal, M.
Improved prediction of therapeutic absorbed doses of radioiodine in the treatment of thyroid carcinoma.
Journal of Nuclear Medicine. Roč. 42, č. 7 (2001), s. 1084-1090. ISSN 0161-5505. E-ISSN 1535-5667
R&D Projects: GA MZd NC4581; GA MZd NN5382; GA ČR GP102/00/D072
Institutional research plan: AV0Z1075907
Keywords : thyroid cancer * radioiodine therapy * pharmacokinetics of 131I
Subject RIV: BB - Applied Statistics, Operational Research
Impact factor: 4.510, year: 2001
We proposed an alternative to a monoexponential model of radioiodine kinetics to obtain a more accurate estimate of absorbed doses to postsurgical thyroid remnants. We suggested that part of the difference between the predicted and the actually absorbed therapeutic doses of 131I, usually explained by radiation damage of thyroid cells, can be attributed to errors resulting from inadequate sampling of data and oversimplified modelling.
Permanent Link: http://hdl.handle.net/11104/0130714
Number of the records: 1