Vliv znečištění ovzduší na poškození a opravu DNA

0385362 - ÚEM 2013 CZ cze J - Journal Article
Rössner ml., Pavel - Mrhálková, Andrea - Uhlířová, Kateřina - Špátová, Milada - Rössnerová, Andrea - Topinka, Jan - Šrám, Radim
Vliv znečištění ovzduší na poškození a opravu DNA.
[The effect of air pollution on DNA damage and repair.]
Ochrana ovzduší. Roč. 24, č. 5 (2012), s. 25-33. ISSN 1211-0337
R&D Projects: GA MŽP(CZ) SP/1B3/8/08; GA ČR GAP503/11/0084; GA MŠMT 2B08005
Institutional research plan: CEZ:AV0Z50390703
Institutional support: RVO:68378041
Keywords : air pollution * gene expression * nucleotide excision repair
Subject RIV: DN - Health Impact of the Environment Quality

The aim of the study was to investigate the impact of air pollution on subjects living in a heavily polluted Ostrava region and in the relatively clean capital city of Prague. The study was conducted in three sampling periods (winter 2009, summer 2009, winter 2010) differing in the concentrations of major air pollutants. Concentrations of studied air pollutants (benzo[a]pyrene, benzene) were significantly higher in the Ostrava region in all sampling periods. Despite this fact the levels of bulky DNA adducts in peripheral blood lymphocytes were significantly elevated in the Ostrava subjects only in winter 2009. During the other two sampling periods, the levels of bulky DNA adducts were higher in the Prague subjects. Multivariate analyses revealed that exposure to B[a]P and particulate matter < 2.5 µm affected bulky DNA adduct levels in the Ostrava subjects, but not in subjects from Prague.
Permanent Link: http://hdl.handle.net/11104/0214633