Morphological characterization of nanofibers: methods and application in practice

0384532 - ÚMCH 2013 RIV US eng J - Journal Article
Širc, Jakub - Hobzová, Radka - Kostina, Nina Yu. - Munzarová, M. - Juklíčková, M. - Lhotka, M. - Kubinová, Šárka - Zajícová, Alena - Michálek, Jiří
Morphological characterization of nanofibers: methods and application in practice.
Journal of Nanomaterials. Roč. 2012, č. 2012 (2012), 327369_1-327369_14. ISSN 1687-4110. E-ISSN 1687-4129
R&D Projects: GA AV ČR KAN200520804; GA ČR GA304/07/1129; GA MŠMT EE2.3.30.0029
Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z50390512; CEZ:AV0Z50520514
Institutional support: RVO:61389013 ; RVO:68378041 ; RVO:68378050
Keywords : nanofibers * electrospinning * morphology
Subject RIV: CD - Macromolecular Chemistry; FH - Neurology (UEM-P); EI - Biotechnology ; Bionics (UMG-J)
Impact factor: 1.547, year: 2012

Biomedical applications such as wound dressing for skin regeneration, stem cell transplantation, or drug delivery require special demands on the three-dimensional porous scaffolds. Besides the biocompatibility and mechanical properties, the morphology is the most important attribute of the scaffold. Specific surface area, volume, and size of the pores have considerable effect on cell adhesion, growth, and proliferation. In the case of incorporated biologically active substances, their release is also influenced by the internal structure of nanofibers. Although many scientific papers are focused on the preparation of nanofibers and evaluation of biological tests, the morphological characterization was described just briefly as service methods. The aim of this paper is to summarize the methods applicable for morphological characterization of nanofibers and supplement it by the results of our research. Needleless electrospinning technique was used to prepare nanofibers from polylactide, poly(ε-caprolactone), gelatin, and polyamide.
Permanent Link: http://hdl.handle.net/11104/0214150