The natural stilbenoid pinosylvin and activated neutrophils: effects on oxidative burst, protein kinase C, apoptosis and efficiency in adjuvant arthritis

0381109 - ÚOCHB 2013 RIV US eng J - Journal Article
Jančinová, V. - Perečko, T. - Nosál, R. - Harmatha, Juraj - Šmidrkal, J. - Drábiková, K.
The natural stilbenoid pinosylvin and activated neutrophils: effects on oxidative burst, protein kinase C, apoptosis and efficiency in adjuvant arthritis.
Acta Pharmacologica Sinica. Roč. 33, č. 10 (2012), s. 1285-1292. ISSN 1671-4083. E-ISSN 1745-7254
R&D Projects: GA ČR(CZ) GA203/07/1227
Institutional research plan: CEZ:AV0Z40550506
Keywords : pinosylvin * reactive oxygen species * adjuvant arthritis
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 2.354, year: 2012

The effects of the naturally occurring stilbenoid pinosylvin on neutrophil activity in vitro and in experimental arthritis are reported. Pinosylvin significantly decreased the formation of oxidants, both extra- and intra-cellularly, and effectively inhibited protein kinase C activation. Pinosylvin administration decreased the number of neutrophils and significantly reduced the amount of reactive oxygen species in blood. Pinosylvin, as an effective inhibitor of neutrophil activity, is potentially useful as a complementary medicine associated with medicaments prescribed for treating persistent inflammation.
Permanent Link: http://hdl.handle.net/11104/0211649