Number of the records: 1
The effects of repeated delivery of angiotensin II AT1 receptor antisense on distinct vasoactive systems in Ren-2 transgenic rats: young vs. adult animals
- 1.
SYSNO ASEP 0380424 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The effects of repeated delivery of angiotensin II AT1 receptor antisense on distinct vasoactive systems in Ren-2 transgenic rats: young vs. adult animals Author(s) Vaněčková, Ivana (FGU-C) RID, ORCID
Dobešová, Zdenka (FGU-C)
Kuneš, Jaroslav (FGU-C) RID, ORCID
Zicha, Josef (FGU-C) RID, ORCID, SAISource Title Hypertension Research. - : Springer - ISSN 0916-9636
Roč. 35, č. 7 (2012), s. 761-768Number of pages 8 s. Language eng - English Country JP - Japan Keywords AT(1) receptor ; BP regulation ; gene therapy ; oligodeoxynucleotides ; vasodilator and vasoconstrictor systems Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects IAA500110902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GAP304/12/0259 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000306106200016 DOI https://doi.org/10.1038/hr.2012.29 Annotation Repeated antisense therapy against Angiotensin II AT1 receptor had transient antihypertensive effects exclusively in young Ren-2 transgenic rats (TGR). The contribution of the renin-angiotensin system to blood pressure maintenance is highly important in homozygous TGR, whereas it is surpassed by sympathetic nervous system in heterozygous TGR Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2013
Number of the records: 1