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Calmodulin and S100A1 Protein Interact with N Terminus of TRPM3 Channel
- 1.0380299 - FGÚ 2013 RIV US eng J - Journal Article
Holakovská, Blanka - Gryčová, Lenka - Jirků, Michaela - Šulc, Miroslav - Bumba, Ladislav - Teisinger, Jan
Calmodulin and S100A1 Protein Interact with N Terminus of TRPM3 Channel.
Journal of Biological Chemistry. Roč. 287, č. 20 (2012), s. 16645-16655. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA ČR(CZ) GAP301/10/1159; GA ČR(CZ) GPP205/10/P308; GA ČR(CZ) GAP207/11/0717; GA ČR(CZ) GD305/03/H148
Institutional research plan: CEZ:AV0Z50110509; CEZ:AV0Z50200510
Keywords : TRPM3 * calmodulin * S100A1 * surface plasmon resonance * fluorescence anisotropy
Subject RIV: BO - Biophysics
Impact factor: 4.651, year: 2012
Using combination of biochemical and biophysical methods we revealed two independent CaM binding domains on TRPM3 N-terminus. Moreover we found out that another Ca2+ binding protein S100A1 binds to these domains with high affinity and competes for these binding sites with CaM
Permanent Link: http://hdl.handle.net/11104/0211040
Number of the records: 1