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Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration
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SYSNO ASEP 0379097 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration Author(s) Kolbaum, J. (DE)
Tartz, S. (DE)
Hartmann, W. (DE)
Helm, S. (DE)
Nagel, A. (DE)
Heussler, V. (CH)
Šebo, Peter (MBU-M) RID, ORCID
Fleischer, B. (DE)
Jacobs, T. (DE)
Breoler, M. (DE)Source Title European Journal of Immunology. - : Wiley - ISSN 0014-2980
Roč. 42, č. 4 (2012), s. 890-900Number of pages 11 s. Language eng - English Country DE - Germany Keywords Immune modulation ; Litomosoides sigmodontis ; Plasmodium Subject RIV EE - Microbiology, Virology R&D Projects GA310/08/0447 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000303157600012 DOI https://doi.org/10.1002/eji.201141955 Annotation Malaria is still responsible for up to 1 million deaths per year worldwide, highlighting the need for protective malaria vaccines. Helminth infections that are prevalent in malaria endemic areas can modulate immune responses of the host. Here we show that Strongy-Ioides ratti, a gut-dwelling nematode that causes transient infections, did not change the efficacy of vaccination against Plasmodium berghei. An ongoing infection with Litomosoides sigmodontis, a tissue-dwelling filaria that induces chronic infections in BALB/c mice, significantly interfered with vaccination efficacy. The induction of P. berghei circumspor-ozoite protein (CSP)-specific CD8+ T cells, achieved by a single immunization with a CSP fusion protein, was diminished in L. sigmodontis-infected mice Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2013
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