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Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration

  1. 1.
    SYSNO ASEP0379097
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleNematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration
    Author(s) Kolbaum, J. (DE)
    Tartz, S. (DE)
    Hartmann, W. (DE)
    Helm, S. (DE)
    Nagel, A. (DE)
    Heussler, V. (CH)
    Šebo, Peter (MBU-M) RID, ORCID
    Fleischer, B. (DE)
    Jacobs, T. (DE)
    Breoler, M. (DE)
    Source TitleEuropean Journal of Immunology. - : Wiley - ISSN 0014-2980
    Roč. 42, č. 4 (2012), s. 890-900
    Number of pages11 s.
    Languageeng - English
    CountryDE - Germany
    KeywordsImmune modulation ; Litomosoides sigmodontis ; Plasmodium
    Subject RIVEE - Microbiology, Virology
    R&D ProjectsGA310/08/0447 GA ČR - Czech Science Foundation (CSF)
    CEZAV0Z50200510 - MBU-M (2005-2011)
    UT WOS000303157600012
    DOI https://doi.org/10.1002/eji.201141955
    AnnotationMalaria is still responsible for up to 1 million deaths per year worldwide, highlighting the need for protective malaria vaccines. Helminth infections that are prevalent in malaria endemic areas can modulate immune responses of the host. Here we show that Strongy-Ioides ratti, a gut-dwelling nematode that causes transient infections, did not change the efficacy of vaccination against Plasmodium berghei. An ongoing infection with Litomosoides sigmodontis, a tissue-dwelling filaria that induces chronic infections in BALB/c mice, significantly interfered with vaccination efficacy. The induction of P. berghei circumspor-ozoite protein (CSP)-specific CD8+ T cells, achieved by a single immunization with a CSP fusion protein, was diminished in L. sigmodontis-infected mice
    WorkplaceInstitute of Microbiology
    ContactEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Year of Publishing2013
Number of the records: 1  

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