Insertional Mutagenesis Strategies in Cancer Genetics

0378894 - ÚMG 2013 RIV US eng M - Monography Chapter
Pečenka, Vladimír - Karafiát, Vít - Dvořák, Michal
Chicken models of retroviral insertional mutagenesis.
Insertional Mutagenesis Strategies in Cancer Genetics. New York: Springer, 2011 - (Dupuy, A.; Largaespada, D.), s. 77-112. ISBN 978-1-4419-7655-0
R&D Projects: GA ČR GA301/09/1727
Institutional research plan: CEZ:AV0Z50520514
Keywords : insertional mutagenesis * chicken model * MAV retroviruses
Subject RIV: EB - Genetics ; Molecular Biology

The introductory part summarizes published results of searching for cancer-related genes obtained using chicken models of insertional mutagenesis and presents new views of mechanisms by which integrated proviruses deregulate host gene expression. The major part of the chapter is devoted to the most advanced model based on MAV-2 retrovirus that has been elaborated recently by the authors. So far the model allowed identification of genes participating in the formation of nephroblastomas, lung and liver hemangiosarcomas, liver carcinomas and cholangiocarcinomas. Most of these tumor types were induced with the help of the new phenomenon discovered recently by the authors: non-tumor cells released into the blood circulation and passing further into tissues strongly promote the formation of a tumor from latent malignant cells primed by MAV-2 insertional mutagenesis. The data described in the chapter are up-to-date and include the newest results of the authors that has not been published yet. The chapter shows that chicken model of cancerogenesis is the prolific one, can advantageously complement mammalian models and contribute to our knowledge of genes, pathways and networks implicated in cancerogenesis leading to data that could translate to human medicine.
Permanent Link: http://hdl.handle.net/11104/0216411