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Sex differences during the course of diet-induced obesity in mice: adipose tissue expandability and glycemic control
- 1.0377129 - FGÚ 2013 RIV GB eng J - Journal Article
Medříková, Daša - Jílková, Zuzana - Bardová, Kristina - Janovská, Petra - Rossmeisl, Martin - Kopecký, Jan
Sex differences during the course of diet-induced obesity in mice: adipose tissue expandability and glycemic control.
International Journal of Obesity. Roč. 36, č. 2 (2012), s. 262-272. ISSN 0307-0565. E-ISSN 1476-5497
R&D Projects: GA MŠMT(CZ) 7E10059; GA MŠMT(CZ) OC08008; GA ČR(CZ) GA303/08/0664
Institutional research plan: CEZ:AV0Z50110509
Keywords : sex differences * inflammation * adipose tissue expandability * insulin sensitivity * mice
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 5.221, year: 2012
Compared with males of the C57BL/6N strain, female mice demonstrate increased capacity for adipocyte enlargement in response to a long-term HF feeding, which is associated with reduced adipose tissue macrophage infiltration and lower fat deposition in the liver, and with better insulin sensitivity. Our data suggest that adipose tissue expandability linked to adiponectin secretion might have a role in the sex differences observed in obesity-associated metabolic disorders
Permanent Link: http://hdl.handle.net/11104/0209373
Number of the records: 1