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N-(2-hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin. I. New synthesis, physicochemical characterization and preliminary biological evaluation
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SYSNO ASEP 0359073 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title N-(2-hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin. I. New synthesis, physicochemical characterization and preliminary biological evaluation Title Polymerní konjugáty založené na bázi N-(2-hydroxypropyl)methacrylamidu s pH-řízeným uvolňováním léčiva. I. Syntéza, fyzikálně-chemická charakterizace a předběžné biologické hodnocení Author(s) Etrych, Tomáš (UMCH-V) RID, ORCID
Mrkvan, Tomáš (MBU-M)
Chytil, Petr (UMCH-V) RID, ORCID
Koňák, Čestmír (UMCH-V) RID
Říhová, Blanka (MBU-M) RID
Ulbrich, Karel (UMCH-V) RIDSource Title Journal of Applied Polymer Science. - : Wiley - ISSN 0021-8995
Roč. 109, č. 5 (2008), s. 3050-3061Number of pages 11 s. Language eng - English Country US - United States Keywords copolymerization ; drug-delivery systems ; water-soluble polymers Subject RIV CD - Macromolecular Chemistry R&D Projects FI-IM2/111 GA MPO - Ministry of Industry and Trade (MPO) UT WOS 257442900041 DOI 10.1002/app.28466 Annotation New method of synthesis of water-soluble polymer-drug conjugates, exhibiting remarkable anticancer activity in mice models, has been developed. In the conjugates, an anticancer drug doxorubicin (DOX) is attached to a polymer carrier based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer via a hydrolytically labile hydrazone bond. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2011
Number of the records: 1