LIM-homeodomain Islet1 transcription factor in neurosensory development of the inner ear

0355379 - BTÚ 2011 eng C - Conference Paper (international conference)
Pavlínková, Gabriela - Fritsch, B. - Bohuslavová, Romana - Kuthanová, Lada
LIM-homeodomain Islet1 transcription factor in neurosensory development of the inner ear.
Meeting abstract book. Praha, 2010, s. 25-25.
[47th Inner Ear Biology Workshop. Praha (CZ), 29.09.2010-01.10.2010]
Institutional research plan: CEZ:AV0Z50520701
Keywords : Neurosensors * transcriptional factors * inner ear
Subject RIV: EB - Genetics ; Molecular Biology

Several transcription factors have been shown to be essential for the generation of auditory sensory hair cells or spiral ganglion neurons. However, cellular context-dependent mechanisms that confer inner ear-specific neuronal or sensory identities are elusive. Using mouse model and in situ hybridization, we show that Isl1 is expressed early during ear development in the otocyst and delaminating sensory neuron precursors at E9.5. We hypothesize that Islet1, which is expressed in the precursors that give rise to neurons and sensory epithelia, plays a role in the cell fate decision of neurosensory cells in the inner ear
Permanent Link: http://hdl.handle.net/11104/0194162