Sourcebook of Models for Biomedical Research

0343754 - ÚŽFG 2011 RIV US eng M - Monography Chapter
Vodička, Petr - Hlučilová, Jana - Klíma, Jiří - Procházka, Radek - Ourednik, J. - Motlík, Jan
The Minipig as an Animal Model in Biomedical Stem Cell Research.
Sourcebook of Models for Biomedical Research. Totowa, New Jersey: Humana Press, 2008 - (Conn, P.), s. 241-248. Medicine. ISBN 978-1-58829-933-8
R&D Projects: GA MŠMT 1M0538
Institutional research plan: CEZ:AV0Z50450515
Keywords : Animal model * Minipig * Neural stem cell
Subject RIV: FH - Neurology

Pigs and miniature pigs are steadily gaining importance as large animal models in the field of regenerative medicine, including stem cell research. With their size, organ capacity, and physiology resembling in several aspects that of humans, pigs are well suited for preclinical experiments and long-term safety studies. In this chapter, we summarize our experience with the isolation and culture of several somatic stem cell populations from fetal and adult pig tissue and briefly review their potential usefulness in future stem cell-based therapies. We also provide protocols for the isolation of fetal porcine neural stem cells (NSCs), adult bone marrow mesenchymal stem cells (MSCs), and epidermal progenitor cells (EPCs) from adult hair follicles.
Permanent Link: http://hdl.handle.net/11104/0186158