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Selective Inhibition of Casein Kinase 1 epsilon Minimally Alters Circadian Clock Period
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SYSNO ASEP 0328977 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Selective Inhibition of Casein Kinase 1 epsilon Minimally Alters Circadian Clock Period Author(s) Walton, K. M. (US)
Fisher, K. (US)
Rubitski, D. (US)
Marconi, M. (US)
Meng, Q.-J. (GB)
Sládek, Martin (FGU-C) RID, ORCID, SAI
Adams, J. (US)
Bass, M. (US)
Chandrasekaran, R. (US)
Butler, T. (US)
Griffor, M. (US)
Rajamohan, F. (US)
Serpa, M. (US)
Chen, Y. (US)
Claffey, M. (US)
Hastings, M. (GB)
Loudon, A. (GB)
Maywood, E. (GB)
Ohren, J. (US)
Doran, A. (US)
Wager, T. T. (US)Source Title Journal of Pharmacology and Experimental Therapeutics. - : American Society for Pharmacology and Experimental Therapeutics - ISSN 0022-3565
Roč. 330, č. 2 (2009), s. 430-439Number of pages 10 s. Language eng - English Country US - United States Keywords circadian clock ; casein kinase 1 epsilon ; inhibitor Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000268150900007 DOI 10.1124/jpet.109.151415 Annotation Casein kinases 1 (CK1) epsilon and delta mutations have dramatic effect on circadian clock period. We have previously shown, that pan-CK1delta/epsilon inhibitor causes a delay in animal models of circadian rhythm, however it remains unclear, whether one of the kinases has predominant role. Here we have used novel selective CK1 epsilon inhibitor to show that wild-type CK1 epsilonhas only minimal effect on circadian clock relative to CK1 delta Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2010
Number of the records: 1