Insect pest management with 2-(4-Hydroxybenzyl)cycIoalkanol derivatives: A 30-year story

0323419 - ÚEB 2009 RIV ZA eng C - Conference Paper (international conference)
Wimmer, Zdeněk - Wimmerová, Martina - Jurček, Ondřej - Svobodová, Hana - Bennettová, Blanka - Hrdý, Ivan - Kuldová, Jelena - Šaman, David - Kolehmainen, E.
Insect pest management with 2-(4-Hydroxybenzyl)cycIoalkanol derivatives: A 30-year story.
[Ochrana před hmyzími škůdci pomocí derivátů 2-(4-hydroxybenzyl)cykloalkanolů: 30-letý příběh.]
International Congress of Entomology 2008. Durban: -, 2008, ---.
[International Congress of Entomology /23./. Durban (ZA), 06.07.2008-12.07.2008]
R&D Projects: GA MŠMT 2B06024
Institutional research plan: CEZ:AV0Z50380511; CEZ:AV0Z50070508; CEZ:AV0Z40550506
Keywords : juvenoid * juvenogen * insect pest control
Subject RIV: CC - Organic Chemistry

Derivatives of 2-(4-hydroxybenzyl)cycloalkanols were designed in late 1970's. Since that time, numbers of compounds have been synthesized and tested as insect juvenile hormone bioanalogs (JHAs). Considering a novel way to implement their practical application, we have elaborated the idea of juvenogens (hormonogenic substances) as novel types of insect pest management agents, Juvenogens are biochemically targeted complex substances, which usually display low biological activity upon topical application, and may be activated either through in vivo biochemical pathways (enzymatic system of living organisms) or through the environmental conditions (humidity, acidity, UV light etc.). They can be synthesized as targeted structures depending on knowledge of the enzymic system of the target insect pests and/or their host plants. These compounds may be more convenient for external application against insects, but not persisting in the environment and displaying as low as possible environmental and/or health risk. In our team, designing and developing new structures has been performed by application of a number of chemoenzymic approaches to get mainly enantiopure compounds available. Subsequent investigation of the structure-activity relationship, and the studies in metabolomics of these compounds followed to get knowledge on potential ecotoxicity of the applied compounds and their metabolites.

Deriváty 2-(4-hydroxybenzyl)cykloalkanolů byly vyvíjeny od 70. let minulého století. Od té doby bylo připravena řada sloučenin pro testování jako bioanalogy hmyzích juvenilních hormonů. Příspěvek shrnuje výsledky tohoto výzkumu.
Permanent Link: http://hdl.handle.net/11104/0171384