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Pore formation by the Bordetella adenylate cyclase toxin in lipid bilayer membranes: Role of voltage and pH
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SYSNO ASEP 0312695 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Pore formation by the Bordetella adenylate cyclase toxin in lipid bilayer membranes: Role of voltage and pH Title Tvorba iontových kanálů adenylát cyklázovým toxinem bakterie Bordetella pertussis v lipidových membránách: Role napětí a pH Author(s) Knapp, O. (DE)
Maier, E. (DE)
Mašín, Jiří (MBU-M) RID, ORCID
Šebo, Peter (MBU-M) RID, ORCID
Benz, R. (DE)Source Title Biochimica Et Biophysica Acta-Biomembranes. - : Elsevier - ISSN 0005-2736
Roč. 1778, č. 1 (2008), s. 260-269Number of pages 10 s. Language eng - English Country NL - Netherlands Keywords adenylate cyclase toxin ; act ; voltage Subject RIV EE - Microbiology, Virology R&D Projects IAA5020406 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000253269500027 DOI 10.1016/j.bbamem.2007.09.026 Annotation In this study we investigated in detail the effect of membrane potential on channel formation by ACT in black lipid bilayer membranes. We demonstrate that the sign of the voltage with respect to the addition of ACT determines the type of channels formed and their voltage dependence. Moreover, calcium ions in millimolar concentration were found to enhance the voltage-dependence of ACT-channels Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2009
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