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Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes
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SYSNO ASEP 0309908 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes Title Příprava modifikovaných nukleosidů, nukleotidů a oligonukleotidů nesoucích komplexy kovů Author(s) Vrábel, Milan (UOCHB-X) RID, ORCID
Hocek, Michal (UOCHB-X) RID, ORCIDSource Title Chemistry of Nucleic Acid Components. - Praha : Institute of Organic Chemistry and Biochemistry ASCR, 2008 / Hocek Michal - ISBN 978-80-86241-29-6 Pages s. 182-185 Number of pages 4 s. Action Symposium on Chemistry of Nucleic Acid Components /14./ Event date 08.06.2008-13.06.2008 VEvent location Český Krumlov Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords DNA ; electrochemical labels ; metal complexes Subject RIV CC - Organic Chemistry R&D Projects GA203/05/0043 GA ČR - Czech Science Foundation (CSF) LC512 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000257885700028 Annotation Series of modified nucleosides and oligonucleotides bearing metal complexes were synthetized. Palladium catalyzed aqueous-phase cross-coupling reactions were used as key step in the synthesis of modified metallo-labeled nucleosides, nucleotides and oligonucleotides. The corresponding Fc modified dNTPs were good sustrates for DNA polymerases and were efficiently incorporated to DNA by primer extension (PEX). The modified nucleic acids are applicable as tools in bioanalysis. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2009
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