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Retargeting polymer coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer
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SYSNO ASEP 0306296 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Retargeting polymer coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer Title Přesměrování polymerem modifikovaného adenoviru k FGF receptorům ovlivňuje jeho účinnost a umožňuje účinné infikování peritoneálního modelu lidského ovariálního nádoru Author(s) Green, N. K. (GB)
Morrison, J. (GB)
Hale, S. (GB)
Briggs, S. S. (GB)
Stevenson, M. (GB)
Šubr, Vladimír (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RID
Chandler, L. (US)
Mautner, V. (GB)
Seymour, L. W. (GB)
Fisher, K. D. (GB)Source Title Journal of Gene Medicine - ISSN 1099-498X
Roč. 10, č. 3 (2008), s. 280-289Number of pages 10 s. Language eng - English Country US - United States Keywords adenovirus ; targeting ; gene therapy Subject RIV CD - Macromolecular Chemistry R&D Projects GA204/05/2255 GA ČR - Czech Science Foundation (CSF) Next source Framework programmes of European Commission CEZ AV0Z40500505 - UMCH-V (2005-2011) DOI 10.1002/jgm.1121 Annotation Transductional targeting of adenovirus following systemic or regional delivery remains one of the most difficult challenges for cancer gene medicine. The numerical excess and anatomical advantage of normal (non-cancer) cells in vivo demand far greater detargeting than is necessary for studies using single cell populations in vitro, and this must be coupled with efficient retargeting to cancer cells. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2008
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