Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension

0142552 - FGU-C 20030162 RIV CZ eng J - Journal Article
Pravenec, Michal - Landa, Vladimír - Zídek, Václav - Musilová, Alena - Kazdová, L. - Qi, N. - Wang, J. - St. Lezin, E. S. - Kurtz, T. W.
Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension.
Physiological Research. Roč. 52, č. 6 (2003), s. 681-688. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR GA305/00/1646; GA ČR GA301/00/1636; GA MZd NB4904
Grant - others:HHMI(US) 55000331
Institutional research plan: CEZ:AV0Z5011922
Keywords : Cd36 * dyslipidemia * transgenic SHR
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 0.939, year: 2003

Transgenic expression of Cd36 in the new lines was associated with significantly decreased serum fatty acids, amelioration of insulin resistance and glucose intolerance but failed to induce any consistent changes in blood pressure as measured by radiotelemetry. The current findings confirm the genetic association of defective Cd36 with disordered insulin action and fatty acid metabolism in the SHR/NIH strain and suggest that Cd36 is linked to other gene(s) on rat chromosome 4 that regulate blood pressure.
Permanent Link: http://hdl.handle.net/11104/0040253