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Mitochondrial ubiquinone (coenzyme Q10): biochemical, functional, medical, and therapeutic aspects in human health and diseases
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SYSNO ASEP 0142140 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Specific properties of coenzyme Q, function in brown adipose tissue cells Author(s) Rauchová, Hana (FGU-C) RID, ORCID
Drahota, Zdeněk (FGU-C) RID, ORCID
Lenaz, G. (IT)Source Title Mitochondrial ubiquinone (coenzyme Q10): biochemical, functional, medical, and therapeutic aspects in human health and diseases / Ebadi M. ; Marwah J. ; Chopra R.. - Arizona : Prominent Press, 2001 - ISBN 0-9668997-3-3 Pages s. 217-229 Number of pages 13 s. Language eng - English Country US - United States Keywords coenzyme Q Subject RIV CC - Organic Chemistry R&D Projects GA303/98/0473 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5011922 - FGU-C Annotation Brown adipose tissue represents a unique model system for demonstration of specific mechanisms participating in the transfer of reducing equivalents between mitochondrial dehydrogenases and coenzyme Q pool. Experimental data indicate that coenzyme Q binding protein is absent in the very active mitochondrial glycerol-3-phosphate enzyme complex. The absence of this protein could be responsible for the capacity of reactive oxygen substances (ROS) production by this enzyme. Glycerol-3-phosphate-dependent production of ROS could be responsible for the induction of apoptosis process and elimination of brown adipose tissue during postnatal development or after a period of hibernation. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2002
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