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RACK1 Targets the Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway To Link Integrin Engagement with Focal Adhesion Disassembly and Cell Motility
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SYSNO ASEP 0098523 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title RACK1 Targets the Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway To Link Integrin Engagement with Focal Adhesion Disassembly and Cell Motility Title RACK1 spojuje signální dráhu „Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase“ s integriny a tím rozložení fokálních adhezí a následně buněčnou migraci Author(s) Vomastek, Tomáš (MBU-M) RID, ORCID
Iwanicki, M. P. (US)
Schaeffer, J. - J. (US)
Tarcsafalvi, A. (US)
Parsons, J. T. (US)
Weber, M. J. (US)Source Title Molecular and Cellular Biology. - : American Society for Microbiology - ISSN 0270-7306
Roč. 27, č. 23 (2007), s. 8296-8305Number of pages 9 s. Language eng - English Country US - United States Keywords protein kinase ; adhesion ; cell Subject RIV EE - Microbiology, Virology R&D Projects IAA500200716 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50200510 - MBU-M (2005-2011) Annotation The ERK cascade is activated in response to a broad spectrum of extracellular signals and regulates many cellular responses, including cell growth, cell differentiation and cell motility. The efficiency, specificity, and localization of the ERK signaling pathway could be achieved by scaffold proteins that tether the ERK cascade core kinases and present these enzymes to specific upstream activators and select downstream substrates. We have identified protein RACK1 as a scaffold protein required for integrin dependent activation of the ERK cascade. Our data suggest that RACK1 tethers ERK pathway core kinases, channel signals from upstream activator integrin to downstream targets at focal adhesions, thus promoting focal adhesion turnover and consequently cell motility Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2008
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