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An approach to pyrrolidine-containing sphingomimetics based on L-tartaricacid chiron
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SYSNO ASEP 0582840 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title An approach to pyrrolidine-containing sphingomimetics based on L-tartaricacid chiron Author(s) Raschmanová, J. Š. (SK)
Fabián, M. (SK)
Sudzina, A. (SK)
Martinková, M. (SK)
Pilátová, M. B. (SK)
Cvačka, Josef (UOCHB-X) RID, ORCID
Kofroňová, Edita (UOCHB-X) RID
Mezencev, R. (US)Article number 133843 Source Title Tetrahedron. - : Elsevier - ISSN 0040-4020
Roč. 153, March (2024)Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords sphingomimetics ; pyrrolidine skeleton ; heterosigmatropic rearrangement ; olefin cross-metathesis reaction ; anticancer profile ; sphingolipids ; synthesis ; cancer OECD category Organic chemistry Method of publishing Limited access Institutional support UOCHB-X - RVO:61388963 UT WOS 001171465000001 EID SCOPUS 85183495719 DOI 10.1016/j.tet.2024.133843 Annotation A synthetic approach to constructing pyrrolidine-containing sphingolipid-like derivatives has been accomplished. The results obtained from biological screening have completed the structure-activity relationships in a series of eight prepared stereoisomeric C-alkyl pyrrolidinediols and elucidated the role of the stereochemistry on the heterocyclic skeleton towards the studied anticancer profile. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2025 Electronic address https://doi.org/10.1016/j.tet.2024.133843
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