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Treatment of phenylalanine and tyrosine in phosphate-buffered saline by plasma-supplied oxygen atoms: Chemical characterization and bactericidal effects
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SYSNO ASEP 0567035 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Treatment of phenylalanine and tyrosine in phosphate-buffered saline by plasma-supplied oxygen atoms: Chemical characterization and bactericidal effects Author(s) Jirásek, Vít (UFP-V)
Tarabová, Barbora (UFP-V) ORCID
Lukeš, Petr (UFP-V) RID, ORCIDNumber of authors 3 Article number 2200079 Source Title Plasma Processes and Polymers. - : Wiley - ISSN 1612-8850
Roč. 19, č. 11 (2022)Number of pages 13 s. Language eng - English Country DE - Germany Keywords amino acids ; chlorination ; nonthermal plasma ; oxidation ; plasma jet Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology R&D Projects GA19-25026S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UFP-V - RVO:61389021 UT WOS 000818913300001 EID SCOPUS 85133014451 DOI https://doi.org/10.1002/ppap.202200079 Annotation Plasma-treated liquid media containing amino acids have been shown to be effective as disinfectants and antitumor agents. The current study presents chemical analyses and bactericidal properties of mixtures formed by the treatment of phenylalanine and tyrosine in phosphate-buffered saline in He/O2 plasma. A major process observed was the formation of amino acid mono- and di-chloramines accompanied by the oxidation of the amino acid aromatic ring. The chemical activity of treated solutions lasted up to 90 min after plasma treatment. After being acidified to ~pH 3, the treated solutions exhibited a bactericidal effect against Escherichia coli. This effect was associated with the post-discharge reactions of amino acid dichloramines and the formation of C-1 nitrile as the final product. Workplace Institute of Plasma Physics Contact Vladimíra Kebza, kebza@ipp.cas.cz, Tel.: 266 052 975 Year of Publishing 2023 Electronic address https://onlinelibrary.wiley.com/doi/10.1002/ppap.202200079
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