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Toxicity of Silver Nanoparticles Supported by Surface-Modified Zirconium Dioxide with Dihydroquercetin
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SYSNO ASEP 0561943 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Toxicity of Silver Nanoparticles Supported by Surface-Modified Zirconium Dioxide with Dihydroquercetin Author(s) Sredojević, D. (RS)
Lazić, V. (RS)
Pirković, I. (RS)
Perisa, J. (RS)
Murafa, Nataliya (UACH-T) RID, SAI
Spremo-Potparevic, B. (RS)
Zivkovic, L. (RS)
Topalović, D. (RS)
Zarubica, A. (RS)
Krivokuća, M. J. (RS)
Nedeljković, J. M. (RS)Number of authors 11 Article number 3195 Source Title Nanomaterials. - : MDPI
Roč. 12, č. 18 (2022)Number of pages 16 s. Language eng - English Country CH - Switzerland Keywords zirconium dioxide nanoparticles ; dihydroquercetin ; silver nanoparticles ; toxicity ; antimicrobial ability Subject RIV CA - Inorganic Chemistry OECD category Inorganic and nuclear chemistry R&D Projects LM2018124 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UACH-T - RVO:61388980 UT WOS 000859594200001 EID SCOPUS 85138689409 DOI 10.3390/nano12183195 Annotation The antibacterial performance and cytotoxic examination of in situ prepared silver nanoparticles (Ag NPs), on inorganic-organic hybrid nanopowder consisting of zirconium dioxide nanoparticles (ZrO2 NPs) and dihydroquercetin (DHQ), was performed against Gram (-) bacteria Escherichia coli and Gram (+) bacteria Staphylococcus aureus, as well as against human cervical cancer cells HeLa and healthy MRC-5 human cells. The surface modification of ZrO2 NPs, synthesized by the sol-gel method, with DHQ leads to the interfacial charge transfer (ICT) complex formation indicated by the appearance of absorption in the visible spectral range. The prepared samples were thoroughly characterized (TEM, XRD, reflection spectroscopy), and, in addition, the spectroscopic observations are supported by the density functional theory (DFT) calculations using a cluster model. The concentration- and time-dependent antibacterial tests indicated a complete reduction of bacterial species, E. coli and S. aureus, for all investigated concentrations of silver (0.10, 0.25, and 0.50 mg/mL) after 24 h of contact. On the other side, the functionalized ZrO2 NPs with DHQ, before and after deposition of Ag NPs, do not display a significant decrease in the viability of HeLa MRC-5 cells in any of the used concentrations compared to the control. Workplace Institute of Inorganic Chemistry Contact Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Year of Publishing 2023 Electronic address https://hdl.handle.net/11104/0334374
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