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iPSCs in Neurodegenerative Disorders: A Unique Platform for Clinical Research and Personalized Medicine
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SYSNO ASEP 0561885 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title iPSCs in Neurodegenerative Disorders: A Unique Platform for Clinical Research and Personalized Medicine Author(s) Pandey, S. (CZ)
Jirásko, M. (CZ)
Lochman, Jan (UZFG-Y)
Chvátal, A. (CZ)
Chottová Dvořáková, M. (CZ)
Kučera, R. (CZ)Number of authors 6 Article number 1485 Source Title Journal of Personalized Medicine. - : MDPI
Roč. 12, č. 9 (2022)Number of pages 18 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords induced pluripotent stem cells (iPSCs) ; Alzheimer's disease ; Parkinson's disease ; diabetic neuropathy ; spinal cord injury ; personalized medicine Subject RIV EB - Genetics ; Molecular Biology OECD category Neurosciences (including psychophysiology R&D Projects NU20-09-00437 GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support UZFG-Y - RVO:67985904 UT WOS 000857061800001 EID SCOPUS 85138617022 DOI 10.3390/jpm12091485 Annotation In the past, several animal disease models were developed to study the molecular mechanism of neurological diseases and discover new therapies, but the lack of equivalent animal models has minimized the success rate. A number of critical issues remain unresolved, such as high costs for developing animal models, ethical issues, and lack of resemblance with human disease. Due to poor initial screening and assessment of the molecules, more than 90% of drugs fail during the final step of the human clinical trial. To overcome these limitations, a new approach has been developed based on induced pluripotent stem cells (iPSCs). The discovery of iPSCs has provided a new roadmap for clinical translation research and regeneration therapy. In this article, we discuss the potential role of patient-derived iPSCs in neurological diseases and their contribution to scientific and clinical research for developing disease models and for developing a roadmap for future medicine. The contribution of humaniPSCs in the most common neurodegenerative diseases (e.g., Parkinson's disease and Alzheimer's disease, diabetic neuropathy, stroke, and spinal cord injury) were examined and ranked as per their published literature on PUBMED. We have observed that Parkinson's disease scored highest, followed by Alzheimer's disease. Furthermore, we also explored recent advancements in the field of personalized medicine, such as the patient-on-a-chip concept, where iPSCs can be grown on 3D matrices inside microfluidic devices to create an in vitro disease model for personalized medicine. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2023 Electronic address https://www.mdpi.com/2075-4426/12/9/1485
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