Number of the records: 1
Comparison of carboxybetaine with sulfobetaine polyaspartamides: Nonfouling properties, hydrophilicity, cytotoxicity and model nanogelation in an inverse miniemulsion
- 1.
SYSNO ASEP 0555583 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Comparison of carboxybetaine with sulfobetaine polyaspartamides: Nonfouling properties, hydrophilicity, cytotoxicity and model nanogelation in an inverse miniemulsion Author(s) Hladysh, Sviatoslav (UMCH-V) RID, ORCID
Oleshchuk, Diana (UMCH-V) ORCID
Dvořáková, Jana (UMCH-V) RID, ORCID
Šeděnková, Ivana (UMCH-V) RID
Filipová, Marcela (UMCH-V) RID, ORCID
Pobořilová, Zuzana (UMCH-V) RID, ORCID
Pánek, Jiří (UMCH-V) RID, ORCID
Proks, Vladimír (UMCH-V) RID, ORCIDArticle number e52099 Source Title Journal of Applied Polymer Science. - : Wiley - ISSN 0021-8995
Roč. 139, č. 19 (2022)Number of pages 14 s. Language eng - English Country US - United States Keywords adsorption ; biocompatibility ; biomaterials Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects GA21-06524S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000736089600001 EID SCOPUS 85122062038 DOI 10.1002/app.52099 Annotation Zwitterionic polymers are promising non-fouling materials widely used for surface modification. Here, we report the synthesis of zwitterionic polyaspartamides bearing carboxybetaine and sulfobetaine prepared via combining the ring-opening reaction of polysuccinimide with 3-(dimethylamino)-1-propylamine and the reaction of the formed tertiary amine side groups with 1,3-propanesultone and 4-bromobutyric acid, respectively. Both sulfobetaine and carboxybetaine polyaspartamides have cationic and anionic charged groups on the same repeat unit, but they differ in negatively charged groups. The chemical structures of the synthesized polymers were confirmed by 1H NMR and FT-IR spectroscopies. The zwitterionic property of polyaspartamides were characterized by zeta potential measurements using wide range of pH. The surface properties mainly anti-protein adsorption abilities and hydrophilicity were tested by surface plasmon resonance analysis, fluorescence microscopy, and contact angle measurements. Importantly, sulfobetaine polyaspartamides demonstrated better both antifouling performance and ability to form more hydrophilic surfaces than carboxybetaine polyaspartamide. Two zwitterionic carboxybetaine and sulfobetaine nanogels were prepared by horseradish peroxidase-mediated crosslinking in an inverse miniemulsion. Results from dynamic light scattering and transmission electron microscopy showed the formation of nanosized spherical particles. Additionally, sulfobetaine and carboxybetaine polyaspartamides had remarkable biocompatibilities, indicating their promise as non-fouling materials for biomedical applications. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2023 Electronic address https://onlinelibrary.wiley.com/doi/10.1002/app.52099
Number of the records: 1