Biodegradable thermoplastic starch/polycaprolactone blends with co-continuous morphology suitable for local release of antibiotics

Gajdošová, Veronika; Strachota, Beata; Strachota, Adam; Michálková, Danuše; Krejčíková, Sabina; Fulín, P.; Nyč, O.; Břínek, A.; Zemek, M.; Šlouf, Miroslav

doi:https://dx.doi.org/10.3390/ma15031101

Number of the records: 1

Biodegradable thermoplastic starch/polycaprolactone blends with co-continuous morphology suitable for local release of antibiotics

1.

SYSNO ASEP	0552875
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Biodegradable thermoplastic starch/polycaprolactone blends with co-continuous morphology suitable for local release of antibiotics
Author(s)	Gajdošová, Veronika (UMCH-V)_{RID, ORCID} Strachota, Beata (UMCH-V)_RID Strachota, Adam (UMCH-V)_{RID, ORCID} Michálková, Danuše (UMCH-V) Krejčíková, Sabina (UMCH-V) Fulín, P. (CZ) Nyč, O. (CZ) Břínek, A. (CZ) Zemek, M. (CZ) Šlouf, Miroslav (UMCH-V)_{RID, ORCID}
Article number	1101
Source Title	Materials. - : MDPI Roč. 15, č. 3 (2022)
Number of pages	22 s.
Language	eng - English
Country	CH - Switzerland
Keywords	thermoplastic starch ; poly(ε-caprolactone) ; polymer blends
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	TN01000008 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
	NU21-06-00084 GA MZd - Ministry of Health (MZ)
	GA19-04925S GA ČR - Czech Science Foundation (CSF)
Research Infrastructure	CzechNanoLab - 90110 - Vysoké učení technické v Brně
Method of publishing	Open access
Institutional support	UMCH-V - RVO:61389013
UT WOS	000760870800001
EID SCOPUS	85123610917
DOI	10.3390/ma15031101
Annotation	We report a reproducible preparation and characterization of highly homogeneous thermoplastic starch/pol(ε‑caprolactone) blends (TPS/PCL) with a minimal thermomechanical degradation and co-continuous morphology. These materials would be suitable for biomedical applications, specifically for the local release of antibiotics (ATB) from the TPS phase. The TPS/PCL blends were prepared in the whole concentration range. In agreement with theoretical predictions based on component viscosities, the co-continuous morphology was found for TPS/PCL blends with a composition of 70/30 wt.%. The minimal thermomechanical degradation of the blends was achieved by an optimization of the processing conditions and by keeping processing temperatures as low as possible, because higher temperatures might damage ATB in the final application. The blends’ homogeneity was verified by scanning electron microscopy. The co-continuous morphology was confirmed by submicron-computed tomography. The mechanical performance of the blends was characterized in both microscale (by an instrumented microindentation hardness testing, MHI) and macroscale (by dynamic thermomechanical analysis, DMTA). The elastic moduli of TPS increased ca four times in the TPS/PCL (70/30) blend. The correlations between elastic moduli measured by MHI and DMTA were very strong, which implied that, in the future studies, it would be possible to use just micromechanical testing that does not require large specimens.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2023
Electronic address	https://www.mdpi.com/1996-1944/15/3/1101

Number of the records: 1