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Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria
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SYSNO ASEP 0547808 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria Author(s) Fewer, D.P. (FI)
Jokela, J. (FI)
Heinila, L. (FI)
Aesoy, R. (NO)
Sivonen, K. (FI)
Galica, Tomáš (MBU-M) RID
Hrouzek, Pavel (MBU-M) ORCID
Herfindal, L. (NO)Source Title Physiologia Plantarum. - : Wiley - ISSN 0031-9317
Roč. 173, č. 2 (2021), s. 639-650Number of pages 12 s. Language eng - English Country DK - Denmark Keywords laxaphycin-b ; membrane permeabilization ; hassallidin-a ; puwainaphycins ; cyclodextrin ; mechanism ; digitonin ; peptides ; product Subject RIV EF - Botanics OECD category Plant sciences, botany Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000668742600001 EID SCOPUS 85109322018 DOI 10.1111/ppl.13484 Annotation Cyanobacteria produce a variety of chemically diverse cyclic lipopeptides with potent antifungal activities. These cyclic lipopeptides have an amphipathic structure comprised of a polar peptide cycle and hydrophobic fatty acid side chain. Many have antibiotic activity against a range of human and plant fungal pathogens. This review article aims to summarize the present knowledge on the chemical diversity and cellular effects of cyanobacterial cyclic lipopeptides that display antifungal activity. Cyclic antifungal lipopeptides from cyanobacteria commonly fall into four structural classes, hassallidins, puwainaphycins, laxaphycins, and anabaenolysins. Many of these antifungal cyclic lipopeptides act through cholesterol and ergosterol-dependent disruption of membranes. In many cases, the cyclic lipopeptides also exert cytotoxicity in human cells, and a more extensive examination of their biological activity and structure-activity relationship is warranted. The hassallidin, puwainaphycin, laxaphycin, and anabaenolysin structural classes are unified through shared complex biosynthetic pathways that encode a variety of unusual lipoinitiation mechanisms and branched biosynthesis that promote their chemical diversity. However, the biosynthetic origins of some cyanobacterial cyclic lipopeptides and the mechanisms, which drive their structural diversification in general, remain poorly understood. The strong functional convergence of differently organized chemical structures suggests that the production of lipopeptide confers benefits for their producer. Whether these benefits originate from their antifungal activity or some other physiological function remains to be answered in the future. However, it is clear that cyanobacteria encode a wealth of new cyclic lipopeptides with novel biotechnological and therapeutic applications. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2022 Electronic address https://onlinelibrary.wiley.com/doi/epdf/10.1111/ppl.13484
Number of the records: 1