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Convex vs concave surface nano-curvature of Ta2O5 thin films for tailoring the osteoblast adhesion
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SYSNO ASEP 0540764 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Convex vs concave surface nano-curvature of Ta2O5 thin films for tailoring the osteoblast adhesion Author(s) Vaidulych, M. (CZ)
Pleskunov, P. (CZ)
Kratochvíl, J. (CZ)
Mašková, Hana (BC-A) ORCID
Kočová, Pavlína (BC-A) SAI, ORCID
Nikitin, D. (CZ)
Hanus, J. (CZ)
Kylián, O. (CZ)
Štěrba, Ján (BC-A) RID, ORCID
Biederman, H. (CZ)
Choukourov, A. (CZ)Number of authors 11 Article number 125805 Source Title Surface and Coatings Technology. - : Elsevier - ISSN 0257-8972
Roč. 393, JUL 15 2020 (2020)Number of pages 8 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords bioactive tantalum metal ; polymer-films ; plasma ; biocompatibility ; titanium ; resistance ; roughness ; implants ; cells ; sio2 ; Convex and concave structure ; Magnetron sputtering ; Gas aggregation cluster source ; Tantalum pentoxide ; Osteoblasts Subject RIV JJ - Other Materials OECD category Textiles Method of publishing Limited access Institutional support BC-A - RVO:60077344 UT WOS 000532676600007 EID SCOPUS 85083514465 DOI 10.1016/j.surfcoat.2020.125805 Annotation In certain medical interventions, temporally introduced bone implants are required to exhibit high bio-compatibility, yet combined with low osseointegration, to allow for their easy removal afterwards. In this work, Ta2O5 surfaces are developed with good biocompatibility and with the osteoblast adhesion regulated by the nano-topography. The surfaces with convex nano-curvature are produced by applying reactive magnetron sputtering of tantalum over sub-monolayers of hydrocarbon plasma polymer particles. Subsequent ultra-sonication leads to the removal of the particles from the coatings and results in the formation of the surfaces with concave nano-curvature. Primary human osteoblasts are found to sustain the viability and the mineralization ability on all kinds of these surfaces, however, Ta2O5 with the concave topography shows restrained adhesion of the cells. The limited cell adhesion is associated with a closed nature of the concave cavities which poses additional potential barriers for protein-mediated cell-surface interactions. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2021 Electronic address https://www.sciencedirect.com/science/article/pii/S0257897220304746
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