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Molecular Aspects of the Development and Function of Auditory Neurons
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SYSNO ASEP 0538962 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Molecular Aspects of the Development and Function of Auditory Neurons Author(s) Pavlínková, Gabriela (BTO-N) RID, ORCID Number of authors 1 Article number 131 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 22, č. 1 (2021)Number of pages 13 s. Language eng - English Country CH - Switzerland Keywords embryonic stem-cells ; spiral ganglion neurons ; inner-ear ; cochlear innervation ; auditory pathways ; genetic mutations Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology R&D Projects GA20-06927S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support BTO-N - RVO:86652036 UT WOS 000606047300001 EID SCOPUS 85098695040 DOI 10.3390/ijms22010131 Annotation This review provides an up-to-date source of information on the primary auditory neurons or spiral ganglion neurons in the cochlea. These neurons transmit auditory information in the form of electric signals from sensory hair cells to the first auditory nuclei of the brain stem, the cochlear nuclei. Congenital and acquired neurosensory hearing loss affects millions of people worldwide. An increasing body of evidence suggest that the primary auditory neurons degenerate due to noise exposure and aging more readily than sensory cells, and thus, auditory neurons are a primary target for regenerative therapy. A better understanding of the development and function of these neurons is the ultimate goal for long-term maintenance, regeneration, and stem cell replacement therapy. In this review, we provide an overview of the key molecular factors responsible for the function and neurogenesis of the primary auditory neurons, as well as a brief introduction to stem cell research focused on the replacement and generation of auditory neurons. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2021 Electronic address https://www.mdpi.com/1422-0067/22/1/131
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